Lignans and related compounds
TARGETMOL CHEMICALS INC Etoposide 500MG
Also available in 1 mL, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 uM). Etoposide has antitumor activity and induces apoptosis and autophagy. Purity 99.95%
Alkali Scientific Etoposide, 1 G
Etoposide, 1g, is a chemotherapy drug used in cancer research to evaluate its effects on tumor cells. This compound inhibits the enzyme topoisomerase II, which is crucial for DNA replication. By blocking this enzyme, etoposide induces DNA damage that leads to cell death, especially in rapidly dividing cells like those found in tumors. The 1g dosage is ideal for large-scale experiments or studies that require high concentrations of the drug. Researchers use this formulation in cancer studies to understand the mechanisms of DNA damage and cell death, as well as to test its efficacy in combination with other chemotherapeutic agents.
Medchemexpress LLC Etoposide impurity 1 | 23363-35-1 | MFCD01725594 | 562.52 g/mol | C27H30O13 | 5 MG
Etoposide impurity 1 is an analytical impurity standard of the chemotherapeutic agent etoposide, supplied for method development, impurity profiling, and quality control. It is provided as a solid material with defined storage recommendations to maintain stability for analytical use.
- Analytical reference standard for impurity profiling and method development.
- White to off-white solid suitable for HPLC and LC-MS analyses.
- Molecular formula C27H30O13; molecular weight 562.52 g/mol.
- Available in small pack sizes, including 5 MG, for trace-level studies.
- Store at 4°C under inert gas; in solvent: -80°C (6 months) or -20°C (1 month).
Alkali Scientific Etoposide, 100 Mg
Etoposide, 100mg, is a chemotherapy drug used in laboratory studies to explore the effects of cancer treatments on tumor cells. By inhibiting topoisomerase II, Etoposide induces DNA damage, which triggers cell death, particularly in rapidly dividing cancer cells. This potent anticancer agent is often used in experiments testing its effects on various cancer cell lines and its potential as part of combination therapies. The 100mg volume is suitable for larger-scale studies, offering an efficient amount for detailed investigation into its mechanism of action, pharmacodynamics, and potential therapeutic applications in oncology.
Alkali Scientific Etoposide, 25 Mg
Etoposide, 25mg, is an anticancer compound used in laboratory research to study the effects of chemotherapy agents. It is commonly used in vitro to examine its ability to inhibit DNA replication and induce apoptosis in cancer cells. Etoposide works by inhibiting topoisomerase II, an enzyme crucial for DNA unwinding during replication. This action leads to DNA strand breaks and ultimately cell death. The 25mg volume is ideal for small-scale laboratory experiments, allowing researchers to test etoposide’s efficacy in various cancer cell lines. It is a crucial reagent in the study of cancer treatment mechanisms and the development of new cancer therapies.
Apexbio Technology LLC Podophyllotoxin 518-28-5 10mM (in 1mL DMSO)
Podophyllotoxin (CAS 518-28-5) is a naturally occurring lignan that acts as a microtubule assembly inhibitor by binding to tubulin thereby disrupting mitotic spindle formation and inhibiting cell division This mechanism underlies its antineoplastic activity making it a valuable tool in studies of cell cycle regulation cytoskeletal dynamics and anticancer drug development Podophyllotoxin is widely used in biomedical research to investigate mechanisms of cytotoxicity and to screen for compounds targeting mitotic pathways The compound is supplied as 100 mg in a glass bottle or 50 mg in a poly bottle
Selleck Chemical LLC Demethyl-Coclaurine S3294-5mg
Demethyl-Coclaurine (Higenamine Norcoclaurine) the key component of the Chinese herb aconite root is a beta-2 adrenergic receptor ( 2-AR) agonist Demethyl-Coclaurine stimulates AKT phosphorylation and requires PI3K activation for the anti-apoptotic effect in cardiomyocytes
Medchemexpress LLC N-Demethyl Ivabradine-d6 hydrochloride | 1246638-08-3 | 98.0% | 1 MG
N-Demethyl Ivabradine-d6 (hydrochloride) is the deuterium labeled N-Demethyl Ivabradine, which is a metabolite of Ivabradine. It is intended for research use only.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC N-demethyl lincomycin hydrochloride | 14600-41-0 | MFCD00008831 | >95.0% | 428.97 | C17H33ClN2O6S | 1 MG
N-demethyl lincomycin hydrochloride is the N-demethylated derivative of lincomycin supplied as the hydrochloride salt for research and analytical applications. It is provided as an impurity reference for impurity profiling and method development in analytical laboratories.
- Hydrochloride salt form for improved handling and solubility.
- Intended for use as an analytical standard and impurity reference.
- Applicable to HPLC and method development workflows.
- Molecular formula C17H33ClN2O6S and molecular weight 428.97 g/mol.
- Available in small-scale quantities suitable for analytical testing.
Alkali Scientific Etoposide, 250 Mg
Etoposide, 250mg, is an important anticancer drug used in laboratory experiments focused on cancer cell biology. This compound targets and inhibits topoisomerase II, an enzyme necessary for the unwinding of DNA during replication, causing DNA strand breaks and leading to cell death. Etoposide is widely studied in various experimental cancer therapies and is used in cell lines to assess its cytotoxicity and apoptotic effects. The 250mg formulation provides a higher dosage for more extensive research or clinical trials, making it useful for testing its effects in combination therapies and other cancer treatment strategies.
Abcam Picropodophylloto x in, IGF-1R inhibitor, 5MG
MW 414.4 Da, Purity >97%. Selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor. Reduces pAkt and pErk1/2. Does not compete with ATP and may inhibit IGF-1R autophosphorylation. Anticancer agent. Active in vitro and in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC 5-O-demethyl-28-hydroxy-avermectin A1a | 96722-46-2 | 96.0% | C48H72O15 | 10MG
5-O-demethyl-28-hydroxy-avermectin A1a is a research-grade chemical impurity and degradation product of avermectin B1a used as an analytical reference in laboratory studies. It is supplied as a high-purity solid for laboratory research and is intended for research use only; safety data and technical documentation are available from the supplier.
Medchemexpress LLC Etoposide (Standard) | 33419-42-0 | 99.6% | 588.56 | 100 MG
Etoposide (Standard) is an analytical standard of Etoposide, intended for research and analytical applications. Etoposide is an anti-cancer chemotherapy agent that inhibits topoisomerase II, thereby stopping DNA replication. It induces cell cycle arrest, apoptosis, and autophagy.
- Serves as a reference standard for assays
- Suitable for qualitative, quantitative, and methodological research experiments (e.g., HPLC, GC, MS)
- Inhibits topoisomerase II
- Induces cell cycle arrest, apoptosis, and autophagy
Medchemexpress LLC Etoposide (Standard) | 33419-42-0 | 99.6% | 588.56 | 250 MG
Etoposide (Standard) is the analytical standard of Etoposide, intended for research and analytical applications. It functions as an anti-cancer chemotherapy agent by inhibiting topoisomerase II, which stops DNA replication. Additionally, Etoposide induces cell cycle arrest, apoptosis, and autophagy.
- Analytical standard for etoposide
- Intended for research and analytical applications
- Inhibits topoisomerase II
- Stops DNA replication
- Induces cell cycle arrest, apoptosis, and autophagy
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
Abcam Picropodophylloto x in, IGF-1R inhibitor, 25MG
MW 414.4 Da, Purity >97%. Selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor. Reduces pAkt and pErk1/2. Does not compete with ATP and may inhibit IGF-1R autophosphorylation. Anticancer agent. Active in vitro and in vivo.
The product is subject to the following: Abcam Restricted Use Statement